Tianeptine Acid 66981-73-5

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General Details
Chemical Name:Tianeptine
Synonyms: COAXIL;TIANEPTINE;Tianeptina;Tianeotine;Brn 1232295;Tianeptinum;
Melting point:129-131°C
HazardClass 6.1(b)
PackingGroup III
Minimum Order Quantity: 100G
Delivery Time: About 4-7 working days
Payment Terms: T/T, Western Union, MoneyGram,Bitcoin
solubilityFreely soluble in water, in methanol and in methylene chloride

Manufacturing Process

A solution of 27.6 g (0.16 mol) of freshly distilled ethyl 7-aminoheptanoate in 40 ml of nitromethane was added all at once and with mechanical stirring to a suspension of 26.2 g (0.08 mol) of 5,8-dichloro-10-dioxo-11- methyldibenzo[c,f]thiazepine(1,2) in 120 ml of nitromethane. The whole was heated to 55°C for 30 minutes, the solvent was then evaporated in vacuo and the residue was taken up in water. The crude ester was extracted with ether. After evaporation of the ether 36 g of crude ester were obtained, and 30 g (0.065 mol) there of were treated under reflux with a solution of 2.8 g (0.07 mol) of sodium hydroxide in 35 ml of ethanol and 25 ml of water. After one hour’s refluxing, the alcohol was evaporated in vacuo. The residue was taken up in 150 ml of water.
The mixture was twice extracted with 75 ml of chloroform and the aqueous phase was evaporated in vacuo. The sodium salt was then dissolved in 150 ml of chloroform, the solution was dried over sodium sulfate and the product precipitated with anhydrous ether.
The salt was filtered off, washed with ether and dried at 50°C. 13 g of sodium 7-[8-chloro-10-dioxo-11-methyldibenzo[c,f]thiazepin-(1,2)-aminoheptanoate,melting with decomposition at about 180°C, were obtained.

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Tests Specifications Results
Description White to yellowish powder, very hygroscopic. Off-white powder, very hygroscopic.
Solubility Freetly soluble In water and ethanol and dichloroethane Complies
Identification (1)By IR, To match with working standard Complies
(2)It gives reaction of sodium Complies
Impurities A ≤0.1% Not detected
Related compounds Any impurity ≤0.1% <0.1%
Total impurities ≤0.4% 0.25%
Residual Solvents Acetidin≤ 0.5% Not detected
Dichloroethane≤ 0.06% Not detected
Methnol≤ 0.3% Not detected
Aceone ≤ 0.5% Not detected
Aconitrile≤0.041% Not detected
Ethnol≤0.5% 0.04%
N, N-dimethylformamide≤0.088% Not detected
Water ≤ 5.0% 1.38%
Assay 99.0%-101.0%(On anhydrous basis) 99.98%
Conclusion Conform to EP8.0

Related products:

Tianeptine sodium Cas 30123-17-2
Tianeptine sulfate Cas 1224690-84-9
Tianeptine Cas 66981-73-5
Tianeptine Ethyl Ester Cas 66981-77-9